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Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity.
Luige, Olivia; Bose, Partha Pratim; Stulz, Rouven; Steunenberg, Peter; Brun, Omar; Andersson, Shalini; Murtola, Merita; Strömberg, Roger.
Chem Commun (Camb) ; 57(83): 10911-10914, 2021 Oct 19.
Article in English | MEDLINE | ID: covidwho-1488037

ABSTRACT

We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.


Subject(s)
Peptide Nucleic Acids/chemistry , Phenazines/chemistry , Pyridines/chemistry , RNA/chemistry , Catalysis , Hydrogen-Ion Concentration , Hydrolysis , Ribonucleases/chemistry , Zinc/chemistry
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